关键词: 近视, 动物模型

Abstract: Many kinds of myopia animal models are commonly used, including guinea pigs, mice, chickens, tree shrews, etc. The traditional form deprivation method is still the most widely used method for myopia modeling, and the modeling is relatively stable after multiple methods of improvement. However, due to the limited occurrence of form deprivation in humans, the application of experimental results to humans still requires caution. With the development of laser surgery, optical defocusing has provided new modeling methods, which are similar to the naturally occurring myopia in humans. However, the current application scope is still limited. The frequency flash stimulation method can induce moderate to low myopia, but the induction range for myopia diopter is still limited. Different animals have different feeding conditions, induction methods, inducible myopia, and model stability. Currently, there is a lack of recognized and high-quality animal model production standards. (Int Rev Ophthalmol, 2023, 47: 503-507)

Key words: myopia, animal model